DETERMINACIÓN SIMULTÁNEA DE ANTINFLAMATORIOS NO ESTEROIDEOS EN AGUA PARA CONSUMO HUMANO MEDIANTE HPLC-DAD
Palabras clave:
Contaminantes emergentes; antinflamatorios no esteroideos; cromatografía líquida de alta eficacia, detector UV-vis multiespectralResumen
El crecimiento de la población urbana presenta una serie de retos técnicos, ecológicos y sociales para asegurar la disponibilidad y calidad de las aguas superficiales por la presencia de contaminantes emergentes, los mismos que en los últimos años han despertado un interés científico por su creciente presencia en medios acuosos. El objetivo de este estudio fue la determinación simultánea de seis antinflamatorios no esteroideos: aspirina (ácido acetil salicílico), diclofenaco, ibuprofeno, ketorolaco, meloxicam y naproxeno, mediante cromatografía líquida de alta eficacia con un detector ultravioleta - visible multiespectral de arreglo de diodos (HPLC-DAD). Se establecieron diferentes puntos de muestreo del agua a lo largo del río Portoviejo, cercanos a zonas de captación de agua para consumo, así como también se recolectaron muestras de agua potable en las ciudades de Manta, Portoviejo y Rocafuerte. Los primeros resultados revelaron que las concentraciones de estos contaminantes se encontraron por debajo de los límites de detección y cuantificación de la técnica de análisis, por lo que no fue posible su cuantificación en niveles por debajo de los µg/mL. Los resultados sugieren que para la evaluación de estos contaminantes se necesita de técnicas analíticas más sensibles para determinar concentraciones de estos fármacos a niveles de ng/L.
Palabras claves: Contaminantes emergentes; antinflamatorios no esteroideos; cromatografía líquida de alta eficacia, detector UV-vis multiespectral.
Abstract
The growth of the urban population triggers a series of technical, ecological and social challenges to ensure the availability and quality of surface water due to the presence of emerging contaminants, which in recent years have aroused scientific interest due to their increasing presence in aqueous media. The objective of this study was the simultaneous determination of six non-steroidal anti-inflammatory drugs (aspirin, diclofenac, ibuprofen, keterolac, meloxicam and naproxen) by high performance liquid chromatography coupled to a diode array detector (HPLC-DAD). Different water sampling points were established along the Portoviejo River near drinking water catchment areas, as well as drinking water samples were collected in the cities of Manta, Portoviejo and Rocafuerte. Initial results revealed that the concentrations of these contaminants were found to be below the analytical technique detection and quantification limits, making impossible to quantify them at µg/L levels, both in surface water and drinking water samples. The results also suggest that more sensitive and accurate analytical techniques are needed for the evaluation of these contaminants to determine concentrations of these drugs at ng/L levels.
Keywords: Emerging pollutants; non-steroidal anti-inflammatory drugs; high performance liquid chromatography, diode array detector.
Información del manuscrito:
Fecha de recepción: 26 de noviembre de 2021.
Fecha de aceptación: 27 de enero de 2022.
Fecha de publicación: 15 de febrero de 2022.
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